Sintesis, Karakterisasi Struktur dan Sifat Optik Nanopartikel Hidroksiapatit/Magnetit

Yuanita Amalia Hariyanto, Ahmad Taufiq, Sunaryono Sunaryono


Hydroxyapatite becomes one of the promising biomaterials to be applied in medical fields due to its special performances such as biocompatible and non-toxic. So that it to improve performance of hydroxyapatite, it is necessary to develop the hydroxyapatite by compositing with magnetite. In this work, the hydroxyapatite/magnetite was synthesized using precipitated method and characterized using XRD, FTIR, SEM-EDAX, and UV-Vis spectrometer for investigating the detailed structure, functional group, morphology, and band gap energy of the prepared sample. The results show that the sample has two phases with high purity i.e. hydroxyapatite and magnetite without any impurities. The data analysis using the Scherrer’s equation shows that the hydroxyapatite/magnetite has particle size about 10 nm. Meanwhile, the data analysis using FTIR indicates the presence of atomic bond from both of hydroxyapatite and magnetite. Morphologically, it is seen that the sample has an agglomeration in the nanometric size. Interestingly, the hydroxyapatite/magnetite has a band gap energy of about 3.8 eV which is in the range of the band gap energy of hydroxyapatite and magnetite.



Nanoparticles; structure; optical property; hydroxyapatite; magnetite

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E. M. Rivera-Muñoz, “Hydroxyapatite-Based Materials: Synthesis and Characterization,” Biomed. Eng. - Front. Chall., 2011.

Herdianto, Nendar. 2011. “Studi Bioresorbabilitas Biokeramik Bhiphasic Calcium Phosphate (BCP) Sebagai Material Pengganti Tulang.” Jakarta: UI.

S. Joschek, B. Nies, R. Krotz, and A. Göpferich, “Chemical and physicochemical characterization of porous hydroxyapatite ceramics made of natural bone,” Biomaterials, vol. 21, no. 16, pp. 1645–1658, Aug. 2000.

Madhumathi, K., K.T. Shalumona, V.V. Divya Rania, H. Tamurab, T. Furuikeb, N. Selvamurugana, S.V. Nair, and R. Jayakumara. 2009. “Wet Chemical Synthesis of Chitosan Hydrogel Hydroxyapatite Composite Membranes for Tissue Engineering Applications.” International Journal of Biological Macromolecules 45: 12–15. doi:10.1016/j.ijbiomac.2009.03.011.

Y. Luo et al., “Docetaxel loaded oleic acid-coated hydroxyapatite nanoparticles enhance the docetaxel-induced apoptosis through activation of caspase-2 in androgen independent prostate cancer cells,” J. Controlled Release, vol. 147, no. 2, pp. 278–288, Oct. 2010.

G. D. Venkatasubbu, S. Ramasamy, G. S. Avadhani, V. Ramakrishnan, and J. Kumar, “Surface modification and paclitaxel drug delivery of folic acid modified polyethylene glycol functionalized hydroxyapatite nanoparticles,” Powder Technol., vol. 235, pp. 437–442, 2013.

P. Ylinen, “Applications of coralline hydroxyapatite with bioabsorbable containment and reinforcement as bone graft substitute: An experimental study,” 2006.

O. Kaygili, S. V. Dorozhkin, and S. Keser, “Synthesis and characterization of Ce-substituted hydroxyapatite by sol–gel method,” Mater. Sci. Eng. C, vol. 42, pp. 78–82, 2014.

J. Trinkunaite-Felsen, A. Prichodko, M. Semasko, R. Skaudzius, A. Beganskiene, and A. Kareiva, “Synthesis and characterization of iron-doped/substituted calcium hydroxyapatite from seashells Macoma balthica (L.),” Adv. Powder Technol., vol. 26, no. 5, pp. 1287–1293, 2015.

A. C. Deymier-Black, F. Yuan, A. Singhal, J. D. Almer, L. C. Brinson, and D. C. Dunand, “Evolution of load transfer between hydroxyapatite and collagen during creep deformation of bone,” Acta Biomater., vol. 8, no. 1, pp. 253–261, 2012.

A. Tesch et al., “Luminomagnetic Eu3+- and Dy3+-doped hydroxyapatite for multimodal imaging,” Mater. Sci. Eng. C, vol. 81, pp. 422–431, Dec. 2017.

S. Mondal et al., “Hydroxyapatite Coated Iron Oxide Nanoparticles: A Promising Nanomaterial for Magnetic Hyperthermia Cancer Treatment,” Nanomaterials, vol. 7, no. 12, p. 426, Dec. 2017.

L. Gu, X. He, and Z. Wu, “Mesoporous Fe3O4/hydroxyapatite composite for targeted drug delivery,” Mater. Res. Bull., vol. 59, pp. 65–68, 2014.

N. Petchsang, W. Pon-On, J. H. Hodak, and I. M. Tang, “Magnetic properties of Co-ferrite-doped hydroxyapatite nanoparticles having a core/shell structure,” J. Magn. Magn. Mater., vol. 321, no. 13, pp. 1990–1995, Jul. 2009.

M. Akrami et al., “Evaluation of multilayer coated magnetic nanoparticles as biocompatible curcumin delivery platforms for breast cancer treatment,” RSC Adv., vol. 5, no. 107, pp. 88096–88107, 2015.

Z. Yang, X. Gong, and C. Zhang, “Recyclable Fe3O4/hydroxyapatite composite nanoparticles for photocatalytic applications,” Chem. Eng. J., vol. 165, no. 1, pp. 117–121, 2010.

S. Valizadeh, M. H. Rasoulifard, and M. S. Dorraji, “Modified Fe3O4-hydroxyapatite nanocomposites as heterogeneous catalysts in three UV, Vis and Fenton like degradation systems,” Appl. Surf. Sci., vol. 319, pp. 358–366, 2014.

B. Kundu et al., “Doxorubicin-intercalated nano-hydroxyapatite drug-delivery system for liver cancer: an animal model,” Ceram. Int., vol. 39, no. 8, pp. 9557–9566, 2013.

L. Dong, Z. Zhu, Y. Qiu, and J. Zhao, “Removal of lead from aqueous solution by hydroxyapatite/magnetite composite adsorbent,” Chem. Eng. J., vol. 165, no. 3, pp. 827–834, Dec. 2010.

S. J. Iyengar, M. Joy, T. Maity, J. Chakraborty, R. K. Kotnala, and S. Ghosh, “Colloidal properties of water dispersible magnetite nanoparticles by photon correlation spectroscopy,” RSC Adv., vol. 6, no. 17, pp. 14393–14402, 2016.

A. M. Shehap and D. S. Akil, “Structural and optical properties of TiO2 nanoparticles/PVA for different composites thin films.,” Int. J. Nanoelectron. Mater., vol. 9, no. 1, 2016.

M. I. Cabaço, M. Besnard, Y. Danten, and J. A. P. Coutinho, “Carbon dioxide in 1-butyl-3-methylimidazolium acetate. I. Unusual solubility investigated by Raman spectroscopy and DFT calculations,” J. Phys. Chem. A, vol. 116, no. 6, pp. 1605–1620, 2012.

O. Acisli, A. Khataee, S. Karaca, A. Karimi, and E. Dogan, “Combination of ultrasonic and Fenton processes in the presence of magnetite nanostructures prepared by high energy planetary ball mill,” Ultrason. Sonochem., vol. 34, pp. 754–762, 2017.

G. G. Utkan, F. Sayar, P. Batat, S. Ide, M. Kriechbaum, and E. Pişkin, “Synthesis and characterization of nanomagnetite particles and their polymer coated forms,” J. Colloid Interface Sci., vol. 353, no. 2, pp. 372–379, 2011.

E. B. Ansar, M. Ajeesh, Y. Yokogawa, W. Wunderlich, and H. Varma, “Synthesis and characterization of iron oxide embedded hydroxyapatite bioceramics,” J. Am. Ceram. Soc., vol. 95, no. 9, pp. 2695–2699, 2012.

C. Huang, Y. Zhou, Z. Tang, X. Guo, Z. Qian, and S. Zhou, “Synthesis of multifunctional Fe3O4 core/hydroxyapatite shell nanocomposites by biomineralization,” Dalton Trans., vol. 40, no. 18, pp. 5026–5031, 2011.

J. Zhang, S. Rana, R. S. Srivastava, and R. D. K. Misra, “On the chemical synthesis and drug delivery response of folate receptor-activated, polyethylene glycol-functionalized magnetite nanoparticles,” Acta Biomater., vol. 4, no. 1, pp. 40–48, 2008.

A. Yazdani, M. Ghazanfari, and F. Johar, “Light trapping effect in plasmonic blockade at the interface of Fe3O4@ Ag core/shell,” RSC Adv., vol. 5, no. 51, pp. 40989–40996, 2015.

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