Overcoming Health Risk of Down Syndrome Child with Obesity: Systematic Review

Prita Dhyani Swamilaksita


Down syndrome (DS) is a condition that occurs due to an abnormal number of chromosomes which is characterized by the presence of an additional chromosome. A child diagnosed with DS has three distinctive characters, namely having a low Intelligence Quotient (IQ), physical and mental limitations and having a weak immune system. Overweight and obesity are nutritional problems that often occur in people with DS, so it is necessary to study how the health risks that can be experienced by DS sufferers with obesity and how to overcome or minimize these risks. This Systematic Review study was conducted using the PubMed/Medline, Science Direct, and Google Scholar search databases. The search was limited to articles in peer-reviewed journals and literature reviews, which were written in English and Indonesian between 2012 and 2022. The study results showed that >40% of obesity occurred in children with DS. Obesity in people with DS can increase the risk of other health problems such as Obstructive Sleep Apnea (OSA) in adults with DS. In addition, dyslipidemia, hyperinsulinemia, NAFLD, Alzheimer's and tumors, and coronary heart disease are frequently reported in obese DS. Therefore, it is necessary to prevent nutritional problems by parents which includes parenting, feeding practices, and eating patterns. In addition, physical activity is needed for children with DS, especially for those who suffer from obesity. Fulfillment of nutrition and a healthy lifestyle throughout pregnancy is also needed to ensure the health of the child born and reduce the risk of having a baby with DS.



Children with Down Syndrome, Down Syndrome with Obesity; Health Problems in Down Syndrome .

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Alghamdi, S., Banakhar , M., Badr , H., & Alsulami , S. (2021). Physical activity among children with down syndrome: maternal perception. International Journal of Qualitative Studies on Health and Well-being , 16 (1), 1932701.

Aswara , E. (2017). Connection Endorsement Social With Strategy Coping with Parents With Down Syndrome Children in SLB Negeri 01 Bantul Yogyakarta ( Doctoral dissertation , Alma Ata University Yogyakarta).

Basil, JS, Santoro, SL, Martin, LJ, Healy, KW, Chini , BA, & Saal, HM (2016). Retrospective study of obesity in children with Down syndrome. The Journal of pediatrics , 173 , 143-148.

Bertapelli , F., Pitetti K., Agiovlasitis , S., and Junior, G. (2016). Overweight and obesity in children and adolescents with Down syndrome—prevalence, determinants, consequences, and interventions. Research in Developmental Disabilities, 57(2016), 181–192. Doi: 10.1016/j.ridd.2016.06.018.

Corona‐Rivera, JR, Nieto‐García, R., Gutiérrez‐Chávez, AS, Bobadilla‐Morales, L., Rios‐Flores, IM, Corona‐Rivera, A., ... & Peña‐Padilla, C. ( 2019). Maternal risk factors for congenital heart defects in infants with Down syndrome from Western Mexico. American Journal of Medical Genetics Part A , 179 (9), 1857-1865.

Dierssen , M., Fructuoso , M., Martinez de Lagran , M., Tutupigi , M., & Barone, E. (2020). Down syndrome is a metabolic disease: altered insulin signaling mediates peripheral and brain dysfunctions. Frontiers in Neuroscience , 14 , 670.

De la Piedra M., Albertib , G., Cerdac , J., Cárdenasd , A., Paula, MA, & Lizamaa , M. (2017). High frequency of dyslipidemia in children and adolescents with Down Syndrome. Rev Chile Pediatrics , 88 (5), 595-601.

Ebensen , AJ (2010). Health conditions associated with aging and end of life of adults with Down syndrome. International review of research in mental retardation , 39 , 107-126.

Erviana , E., & Hidayati , T. (2019). Analysis of Influencing Factors _ Obesity In People With Disability Intellectuals : A Literature Review . Avicenna: Journal of Health Research , 2 (1).

Emerson, E. and Hatton, C. (2014) Health Inequalities and People with Intellectual Disabilities. Cambridge University Press, Cambridge. https://doi.org/10.1017/CBO9781139192484 .

Esposito, PE, MacDonald, M., Hornyak , JE, and Ulrich, DA (2012). Physical activity patterns of youth with down syndrome, Intellectual and Developmental Disabilities, 50(2), 109–119.

FAO/WHO/UNU. (2001). Human Energy Requirements. Rome: FAO/WHO/UNU.

Fauziyah , DR, & Wirjatmadi , RB (2019). Sufficiency Level Difference Energy And Activity Physical Activity in Overweight and Non-Overweight Adolescence with Down Syndrome]. Indonesian Nutrition Media , 14 (2), 164-169.

Gameren-Oosterom , H., van Dommelen , P., Schönbeck , Y., Oudesluys -Murphy, AM, van Wouwe , JP, & Buitendijk , SE (2012). Prevalence of overweight in Dutch children with Down syndrome. Pediatrics , 130 (6), e1520-e1526.

Gazizova , D., Puri , BK, Singh, I., & Dhaliwal, R. (2012). The overweight: Obesity and plasma lipids in adults with intellectual disability and mental illness. Journal of Intellectual Disability Research, 56(9), 895–901. https://doi.org/10.1111/j.1365-2788.2011.01468.x

Hsieh, K., Rimmer , JH, & Heller, T. (2014). Obesity and associated factors in adults with intellectual disability. Journal of Intellectual Disability Research, 58(9), 851–863. https://doi.org/10.1111/jir.12100 .

Krause et al . (2016). Obesity in adolescents with intellectual disability: Prevalence and associated characteristics. Elseiver 10(5): 520-530.

Koritsas , S., & Iacono , T. (2016). Weight, nutrition, food choice, and physical activity in adults with intellectual disability. Journal of Intellectual Disability Research, 60(4), 355–364. https://doi.org/10.1111/jir.12254 .

Magge , SN, Zemel , BS, Pipan , ME, Gidding , SS, & Kelly, A. (2019). Cardiometabolic risk and body composition in youth with down syndrome. Pediatrics , 144 (2).

Mundijo , T., & Arsyad , KHM (2019). Distribution Number of Children With Down Syndrome In Two Group Mother's Age at the Foundation for the Development of Disabled Children (YPAC) Palembang in 2012. Syifa'MEDIKA : Journal of Medicine and Health , 3 (2), 71-81.

Nawawi, AM, Gartika , M., & Soewondo , W. (2018). Chronological age and dental age using Demirjian in down syndrome children. Am J Appl Sci , 15 (3), 182-5.

Nixon, DW (2018). Down syndrome, obesity, alzheimer's disease, and cancer: A brief review and hypothesis. Brain sciences , 8 (4), 53.

Paul Y., Barnard, M., Swanepoel, M., Ellapen , TJ, & Hammill, HV (2019). The health benefits of exercise therapy for patients with Down syndrome: A systematic review. African journal of disability , 8 (1), 1-9.

Pienaar, D. (2012). Music Therapy for Children with Down Syndrome: Perceptions of Caregivers in a Special School Setting. Kairaranga , 13 (1), 36-43.

Pierce, M., Ramsey, K., & Pinter, J. (2019). Trends in obesity and overweight in Oregon children with Down syndrome. Global pediatric health , 6 , 2333794X19835640.

Pitchford, EA, Hasson, RE, Hornyak , JE, Lumeng , JC, Peterson, KE, & Ulrich, DA (2019). Diurnal cortisol and obesity in adolescents with and without Down syndrome. Journal of Intellectual Disability Research , 63 (12), 1401-1412.

Pramidi , M., Gartika , M., & Soewondo , W. (2019). Comparison Between Fone's Method and Modified Bass Method of Toothbrushing for Children with Down Syndrome in West Java, Indonesia. Journal of Islamic Dental Association of Iran , 31 (2), 93-97.

Propst, EJ, Amin, R., Talwar, N., Zaman, M., Zweerink , A., Blaser, S., ... & Narang, I. (2017). Midline posterior glossectomy and lingual tonsillectomy in obese and nonobese children with down syndrome: biomarkers for success. The Laryngoscope , 127 (3), 757-763.

Rahmawati , LA (2016). Connection Among mother's perception, knowledge level of nutrition mother, pattern of food consumption, and physical activities with nutritional status of children with down syndrome (Doctoral dissertation, Bogor Agricultural University (IPB)).

Real De Asua , DR, Parra, P., Costa, R., Moldenhauer, F., & Suarez, C. (2014). A cross-sectional study of the phenotypes of obesity and insulin resistance in adults with Down syndrome. Diabetes & Metabolism Journal , 38 (6), 464-471.

Robertson, J., Emerson, E., Baines, S., & Hatton, C. (2014). Obesity and health behaviors of British adults with self-reported intellectual impairments: a cross sectional survey. BMC Public Health, 14(1), 219. https://doi.org/10.1186/1471-2458-14-219 .

Ruiz, AG, Gao, D., Ingram, DG, Hickey, F., Haemer , MA, & Friedman, NR (2019). Does tonsillectomy increase obesity risk in children with Down syndrome?. The Journal of pediatrics , 211 , 179-184.

Swamilaksita , PD, Harna , H., Sa'pang , M., Novianti , A., & Kusumaningtiar , DA (2021, March). Education nutrition Effective Upgrade Knowledge Consumption Food Healthy and Safe for Down Syndrome Children. In National Seminar & Call Of Papers Research And Community Service (Vol. 1, No. 01).

Tamin , TZ, Idris, FH, Mansyur , M., & Syarif , DR (2014). Prevalence and determinants of obesity in students with intellectual disability in Jakarta. Medical Journal of Indonesia, 23(2), 106–111. https://doi.org/10.13181/mji.v23i2.688 .

Tershnjaku and Kadolli . (2020). Overweight And Obesity In Community With Down Syndrome. Research in Physical Education, Sport and Health 4.

The Department of Health. (2017). Australia's physical activity and sedentary behavior guidelines . Australian Government: Department of Health. Accessed from http://www.health.gov.au/internet/main/publishing.nsf/content/health-pubhlth-strateg-phys-act-guidelines .

Valentini , D., Alisi , A., di Camillo, C., Sartorelli , MR, Crudele , A., Bartuli , A., ... & Villani, A. (2017). Nonalcoholic fatty liver disease in Italian children with Down syndrome: prevalence and correlation with obesity-related features. The Journal of Pediatrics , 189 , 92-97.

Yahia, S., El- Farahaty , RM, El- Hawary , AK, El- Hussiny , MA, Abdel- Maseih , H., El- Dahtory , F., & El- Gilany , AH (2012). Leptin, insulin and thyroid hormones in a cohort of Egyptian obese Down syndrome children: a comparative study. BMC endocrine disorders , 12 (1), 1-7.

DOI: http://dx.doi.org/10.17977/um005v6i22022p205


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